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Shallow injection depth (injecting too close to the skin surface rather than into subcutaneous fat) concentrates the solution where nerve endings are denser
The -asp3 peptides showed no effect in comparison to vehicle
many patients see normalized androgen levels Common Side Effects Most side effects are gastrointestinal and tend to improve over time: Nausea (most common, usually mild-moderate, improves after 2-3 weeks at each dose) Decreased appetite (this is part of the therapeutic effect) Diarrhea or constipation Injection site reactions (mild redness or itching) Fatigue (usually temporary during dose escalation) Monitoring For PCOS patients on tirzepatide, we recommend regular monitoring including: Fasting insulin and glucose (every 3 months) HbA1c (every 3-6 months) Testosterone (total and free) and DHEA-S DEXA body composition scan at baseline and every 6 months Lipid panel and inflammatory markers Menstrual cycle tracking Tirzepatide vs Semaglutide for PCOS Both tirzepatide and semaglutide are effective GLP-1 medications, but there are important differences for PCOS patients
After provider approval, you will be given a Tirzepatide injection at the dose level recommended by the provider once every week
