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By reducing NNMT catalytic activity, the compound allows researchers to evaluate how limiting nicotinamide methylation influences: In vitro and in vivo experimental models (non-clinical, non-human) have demonstrated that NNMT suppression leads to measurable changes in cellular energy markers and adipocyte behavior
PMID 19948694
The published preclinical work (Neelakantan et al., referenced via PMC5826726) reported clean safety at 20 mg/kg subcutaneous in mice over 11 days
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