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For context, the brains own control of sleep is complex and multi-layered, which is part of why a single peptide rarely fixes sleep on its own (a review of how the hypothalamus regulates sleep and circadian rhythms)
Subclinical signs of peripheral PN could be found in oral LDopa treated patients during the course of the disease, and low Vit B12 levels may facilitate the development of a clinically manifest PN
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