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When taken orally, B12 may not absorb efficientlybut an injection bypasses the digestive system and goes directly into the bloodstream, ensuring maximum effectiveness
Superoxide can rapidly combine with nitric oxide (NO) to form peroxynitrite (ONOO - ), the strongest oxidizing agent in vivo ( 19)
Afamelanotide is FDA-approved for EPP at 16 mg subcutaneous implant every 60 days roughly 2 mg/day of continuous release (Langendonk et al., 2015)
This phase also finalized the dose
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