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Quantification of 2HG enantiomers 2HG quantification in SCD erythroblasts was performed as we previously described 24 by liquid chromatographymass spectrometry (LC-MS/MS) after derivatization using N-(p-Toluenesulfonyl)-L-phenylalanyl Chloride (TSPC) on the LC-ESI-MS/MS system
Intriguingly, for secondary outcome analyses, oral semaglutide was strongly associated with all-cause and cardiovascular death reduction but not non-fatal events while dulaglutide and subcutaneous semaglutide mainly reduced non-fatal stroke but not mortality
Semaglutide medication belongs to a class of medication known as GLP-1 receptor agonists
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