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The International Society of Sports Nutrition position stand states: "The vast majority of studies indicate that creatine supplementation does not adversely affect markers of renal stress in healthy individuals when taken at recommended doses." (Kreider et al., JISSN, 2017) Losartan's Renal Protection Is the Stronger Long-Term Story The IDNT trial (N=1,715) and RENAAL trial (N=1,513) both demonstrated that ARB therapy including losartan reduces progression to end-stage renal disease in patients with type-2 diabetic nephropathy by 20 to 28% compared to placebo or amlodipine controls
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