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Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation
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10.1136/openhrt-2018-000993 Open Heart
![malignant psammomatous melanotic schwannoma presenting as colonic polyps | Virchows Archiv PDF] Melanotic Schwannoma of the](https://www.frontiersin.org/api/ipx/w=1200&f=png/https://www.frontiersin.org/files/Articles/1448112/fonc-14-1448112-HTML/image_m/fonc-14-1448112-g001.jpg)
In the pathogenesis of MASLD, the oxidation of accumulated fatty acids in hepatocytes leads to increased ROS production and subsequent formation of MDA [132]
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Armaan HH, Nazrolu M
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