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This hyperglucagonaemia is observed in most forms of diabetes, in humans and animal models [43,44,45]
Interestingly, atypical Spitz tumor shares at least with PEM a peculiar biological behavior, featuring a high incidence of nodal metastases with a very low incidence of distant metastases (41, 47): such as unique biological property that strongly favors ultrasonograpy monitoring over sentinel node biopsy in the clinical management of such cases (47, 48)
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