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The freeze-thaw cycle can fracture the peptides delicate structure, denaturing it and reducing its efficacy
This result suggests that the tetrameric integrity of Hb is essential for KDS12025-mediated H 2 O 2 decomposition
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Furthermore, although SGLT2is exhibited remarkable efficacy for reducing cardiovascular events, concerns were raised regarding the safety of these drugs in terms of limb events due to the increased incidence of amputations observed in the CANagliflozin cardioVascular Assessment Study (CANVAS) [10], with an almost twofold increase in risk
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