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To optimize drug design and develop therapies targeted at disease mechanisms involving the BBB or to improve drug delivery to the CNS, BBB models are required that adequately reflect in vivo conditions

Constant intense light exposure (500010000 lux for 2448 hours in albino Sprague-Dawley rats) produces reproducible photoreceptor apoptosis quantified by outer nuclear layer thickness (TUNEL staining, OCT measurement) and electroretinography (ERG a-wave amplitude reflecting photoreceptor function)

Some researchers also explore combining GLP-1 therapy with other weight loss peptide stacks to enhance results, though this should only be done under medical supervision

Avoid strenuous activity targeting the injection area for a few hours