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10.3389/fphar.2020.593225 19 QuX.ZhaiB
In our own work, mature osteoblast conditional knockouts of igf-1r generated via an osteocalcin promoter-driven Cre recombinase have excellent postnatal survival with growth rates that resemble wild-type animals
Phase Maximum dose Weeks 17-20+ Weekly Dose 12 mg Notes Highest dose studied
In longer studies, around half of the participants lost 15% of their body weight at 68 weeks, and nearly a third lost 20%
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