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In lung adenocarcinoma, CAF-specific long non-coding RNA, LINC01614, packaged in exosomes derived from CAFs, interacts directly with ANXA2 and p65 to promote NF-B activation

N Engl J Med 389:10691084 Watanabe K, Wilmanski T, Diener C et al (2023) Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention

Ro's clinical oversight is competent but does not include routine advanced biomarker monitoring beyond what FDA guidelines require

The first conditional recommendation advises the use of GLP-1 drugs by adults, except pregnant women, for long-term obesity treatment, while the second suggests interventions like a healthy diet and physical activity to be offered alongside the medicines