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11 kg body weight reduction in the SURPASS-4 trial), preserve the eGFR slope and reduce the UACR [57, 58]
However, real-world outcomes depend heavily on consistent dosing, adherence, and individual metabolic factors
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Absolute contraindications include: Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to tirzepatide or any excipients According to FDA labeling, tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis
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