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Without carefully designed mechanistic experiments, it is difficult to determine whether the peptide acts directly within central compartments or indirectly through peripheral vascular, immune, or gut-brain signaling pathways

The first is Huppke-Brendel Syndrome, a severe neurodevelopmental disorder characterized by severe intellectual disability, motor deficits, and progressive neurodegeneration

For instance, studies using these models have demonstrated that ferroptosis can be induced by oxidative stress and hypoxia, leading to trophoblast dysfunction and miscarriage (Aslanian-Kalkhoran et al., 2022)