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There are now more options available than ever, including Foundayo (orforglipron) a new oral GLP-1 pill approved in April 2026 that can be taken any time of day without food or water restrictions
However, through several magnetic resonance spectroscopy studies (MRS) it has been shown that GSH levels are significantly decreased in the hippocampus, frontal, and cingulate cortices early in AD progression (Mandal et al., 2022)
Consistent with this, co-administration of the GLP-2R agonist h(Gly 2 )GLP-2 and exendin-4 increases small intestinal weight and length to a greater extent compared to the agonists administered alone (Koehler et al., 2015)
However, the body mass index (BMI) does not fully explain the increased risk of CVD in diabetics
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