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Rather, these signals reflect context-dependent processes that can drive both beneficial and detrimental outcomes, ranging from tissue repair and neuroprotection to inflammation and neurodegeneration
In particular, the iodothyronine deiodinases (DIO) and glutathione peroxidases (GPX1) play an essential role in thyroid physiology and safeguard against diseases caused by immunological dysregulation and oxidative stress (OS) [6]
Not to say it can't improve, but it's lower and the probability of adverse issues is higher
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