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Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort
Just as hypertension is rarely managed optimally with a single mechanism of action, complex metabolic dysfunction requires a multi-targeted approach
Side effects Another thing to consider with these weight loss drugs is the potential side effects
MOTS-c also influences the folate cycle through AICAR accumulation [2], raising an unresolved question about interaction with methotrexate or other antifolate medications
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