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Introduction Amyotrophic lateral sclerosis (ALS) is a complex multi-pathogenic neurodegenerative disorder primarily characterized by the loss of upper motor neurons in the brain and lower motor neurons in the spinal cord and the brain stem (Robberecht and Philips, 2013)

GLP-1, or Glucagon-like Peptide-1, is a hormone produced in the gut, specifically by the L cells of the small intestine and colon

Specifically, lactate accumulation contributes to an acidic microenvironment, which can promote the release of free iron from ferritin (ferritinophagy) or alter the function of transferrin receptors, thereby increasing the labile iron pool required for the Fenton reaction

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