(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway
According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohns MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion
Test Methods How to Measure Your Vitamin B12 Status Even with a good B12 intake through the diet, the supply is not always safe
Journal of Molecular Pharmacology , 58(3), 112-118