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Minor injury: 24 weeks at 250500 mcg/day Severe injury or surgery: 46 weeks, up to 1,000 mcg/day Gut repair: 46 weeks oral or SubQ Neurological support: 48 weeks Response time varies, and there is not enough high-quality human evidence to promise improvement within a specific number of days, especially in pain reduction and mobility

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This reduces variables that can influence both safety and outcomes compared with self-managed use

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