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Early research suggests this effect accounts for 2-4% of additional weight loss beyond what dual agonism achieves, a number that compounds significantly over a 48 to 68 week treatment period
These include semaglutide, exenatide, liraglutide, and dulaglutide
Why These Concerns May Not Apply to Humans Although these animal studies raised red flags, human physiology suggests that the findings in rodents may not apply to humans
A cross-sectional study of older adults treated with semaglutide reported a prevalence of reduced muscle mass of 27.7%, reflecting the high baseline risk in this population rather than drug-specific effects [24]
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