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This led to the US FDA approval of Ozempic to reduce cardiovascular risk in this specific patient population in 2020 In the HARMONY Outcomes trial, patients with type 2 diabetes and cardiovascular disease who took the GLP-1 medication saw a 22% reduction in major adverse cardiovascular events compared to placebo
The Cardiovascular Biology of Glucagon-Like Peptide-1
Semaglutide has been shown to help individuals with type 2 diabetes achieve better blood sugar control and lose weight
These compounds work individually and together through several mechanisms of action, including stimulating the bodys metabolic master switch AMP-activated protein kinase (AMPK), an enzyme that acts to burn stored fat and inhibit the creation of new fat cells
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