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Those receiving an SGLT2 inhibitor were less likely to have an adverse safety event than adults receiving a DPP-IV inhibitor (HR = 0.81

and individuals largely from China

Kawai, S., Takagi, Y., Kaneko, S

First, some of the muscle change happens with any rapid weight loss, and a portion may be a normal adjustment to a smaller body rather than harmful wasting (Mocciaro and colleagues, BMJ Nutrition Prevention and Health , 2025)