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The relatively short study duration of 30 weeks also warrants longer-term future studies to confirm the current findings

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Tests may include early morning serum cortisol, 24-hour urinary free cortisol, late-night salivary cortisol, or dynamic tests such as the dexamethasone suppression test and short Synacthen (ACTH stimulation) test for suspected adrenal insufficiency

Significant improvements in fasting glucose or weight may justify more conservative escalation, while absence of improvement may prompt discussion of dose timing or medication adherence