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PMID: 20190196 Reported Macrocycle stability Lactam-bridged backbone confers proteolytic stability The side-chaintoside-chain lactam bridge between Asp(2) and Lys(7) is reported in macrocyclization-strategies reviews to confer proteolytic stability relative to linear -MSH and to constrain the receptor-binding pharmacophore (the conserved His-Phe-Arg-Trp / HFRW core, with D-Phe at position 4 of the cycle in PT-141)
Meal timing and composition matter more than you might expect
Emerging types such as diabetes type 3, which is associated with Alzheimers disease, and type 4 and type 5, often linked to specific genetic or lifestyle factors, represent growing segments that are gaining attention from pharmaceutical companies
In February 2024, Better Choice Company (BTTR) acquired Aimia Pet Healthco to develop GLP-1 drugs in the form of treats and toppers to safely combat pet obesity. While we dont have details of what theyre working on, theyre one of several companies bringing these types of weight loss medications to the veterinary market
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