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A multivitamin may be considered for patients with significantly reduced food intake or documented nutritional gaps, though the US Preventive Services Task Force notes insufficient evidence for routine multivitamin use in generally healthy adults
10.1097/00003086-199302000-00042 58 KawaiT.MiekiA.OhnoY.UmemuraM.KataokaH.KuritaS.et al (1993)
The downstream cellular effects (AMPK activation, mitochondrial biogenesis, gene expression changes) persist far longer
The dose-response curve in clinical trials was clean and linear
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