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Diabetes Med (2003) 20(6):5067

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Individuals with T2DM are at a high risk of developing atherosclerosis, with PAD representing the clinical presentation associated with the poorest prognosis vs the involvement of other vascular territories.25 Unlike non-diabetic individuals, those with T2DM show more severe clinical signs, partly due to concurrent neuropathy and a predominantly distal distribution of PAD, thereby increasing the risk of complications.26,27 A recently published meta-analysis by Ashraf et al