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The biochemical mechanisms of androgenic alopecia have not been fully understood, but we know that the connection of dehydrotestosterone to receptors in the hair follicles eventually leads to atrophy of the blood vessels that supply the follicles with blood

Clinical data confirms that intestinal delivery is measurably more efficient

Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use

The following sgRNAs for GGT1 CRISPRi were used: sgGGT1 1 (HL-ID: 3) forward: 5-CACCGGTGCCTCCCACTGTCCGCCG-3