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MOTS-c targets various organs through the circulation, including the lungs 13,14,15,16 , spinal cord 17 , skeletal muscles 12,18 , adipose tissues 13,19,20,21,22,23 , brain 19,24 , liver 13,15,21,22,25,26 , bone 20,27,28,29,30 , spleen 13,15 , kidney 13,15 , heart 13,15,31,32,33,34 , blood vessels 33,35 , skin 22 , and the small intestine 22

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