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Deficiency is rare in the developed world since meat is widely available and most grains and cereals are fortified with thiamine, but can occur in alcoholics and people who have undergone gastric bypass surgery
Rather than viewing depression, fatigue, insomnia, irritability, cognitive decline and PTSD-like symptoms only as psychiatric problems, the protocol evaluates neuro-inflammation, hypothalamic-pituitary dysfunction, hormone deficiencies, neurosteroids, metabolic health and inflammatory signaling that may be impairing recovery
PMID 24848508
Lack of FDA approval and standardized clinical data limits confirmed use in medical practice despite promising preclinical findings
