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In Parkinsons disease, patients complain of gastrointestinal symptoms years prior to diagnosis [95, 109]
[1] That is a genuinely encouraging preclinical safety signal but it is a short-duration observation in mice, not a toxicology program and not a human safety finding
Takeaway: Shed provides medical evaluation and telehealth follow-up, but patients should confirm how structured and frequent monitoring is managed
Downregulated metabolites included threonine (impaired protein synthesis), histidine, tryptophan, lactate, methionine, formate, arginine, and hydroxytetradecanoylcarnitine
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