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These divergent findings likely reflect heterogeneity in study design, mechanisms of action of the drugs evaluated, duration of follow-up, and the degree of metabolic phenotyping across populations
Allen, L
what differs is the regulatory pathway and the elimination of brand-name markup
In a 2017 study using human vascular endothelial cells and a chick chorioallantoic membrane assay, Hsieh and colleagues reported that BPC-157 exposure increased VEGFR2 mRNA and protein expression, promoted VEGFR2 internalization (an effect blocked by the endocytosis inhibitor dynasore), and time-dependently activated the VEGFR2-Akt-eNOS axis without a corresponding increase in VEGF-A (Hsieh et al., 2017)
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