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Using TUBE2 (tandem ubiquitin-binding entity 2), which serves as a pan-ubiquitin chain binder when four repeats of the UBA1 domains from HR23A are tandemly fused 29 , we found that OTUD5 pan-ubiquitylation was enhanced by the expression of wild-type, but not catalytically inactive (C1959A), TRIP12 (Fig
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However, there was no significant reduction in the risk of adverse cardiovascular events or mortality in a previous systematic review and meta-analysis of clinical trials examining the effects of lifestyle modification [6]
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