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In an accompanying editorial, Dr Sanjay Patel of the University of Pittsburgh, said an evaluation of further metrics would be necessary to fully understand the magnitude of clinical benefit and allow comparisons with existing therapies for obstructive sleep apnoea

Retatrutide is the first medication to mimic three hormones, GLP-1, GIP and glucagon, rather than the one or two that current medications use

Compounded tirzepatide contains the same active ingredient and should be dosed on the same once-weekly schedule

Substitution caution: Do not assume oral semaglutide, compounded semaglutide, or another GLP-1 medicine is equivalent