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Collectively, a rational design strategy that integrates structure-guided optimization and targeted exploitation of isoform-specific residues within both the active site and selectivity pockets can minimize off-target interactions and enhance both safety and translational potential
The relatively fast absorption and clearance of nasal peptides means multiple smaller doses can maintain more consistent blood levels than a single large dose
PS and BaP induce kidney damage in mice To monitor the health of the mice during drug administration, body weights and organ coefficients were measured and recorded on a weekly basis
10.1007/s11064-011-0544-9 49 FahmyH
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