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TGR inhibitors do not react covalently with GSH, selenocysteine, or TGR, and inhibition of TGR is reversible To evaluate stability of the TGR inhibitors in the presence of GSH and selenocysteine, compound 2 and a known covalent inhibitor of TGR, TRi-1 20,45 , were incubated with GSH or the N-Boc protected methyl ester of selenocysteine, and the reaction mixtures were analyzed by LCMS (Supplementary Figs
10.1093/brain/aww003 Brain 88 GuoF.LiuX.CaiH.LeW
Reading Each Dose on the Ladder Trial and clinical protocols seek the lowest dose that keeps the relevant markers moving without unacceptable side effects
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