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However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]
Supernatant was collected by centrifugation at 30,000 rpm for 30 min
CPT Pharmacometrics Syst Pharmacol 2024;13:494503 (tirzepatide): against a 90 kg reference, +22% at 70 kg and 33% at 120 kg
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