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The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology

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Instead, therapeutic efficacy increasingly depends on integrated protocols, monitored through biomarkers that reflect dynamic changes across molecular, cellular, and network levels

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10.1016/j.drugalcdep.2005.12.007 Drug Alcohol Depend

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