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In populations who cannot exercise due to frailty, physical disability, or cardiovascular limitations, MOTS-c represents one of the most compelling candidates in the emerging class of pharmacological exercise mimetics
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Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes
And what I've learned working with patients is if you take away the easily enticed eater and they don't have to count calories all the time, and they can start eating healthier because they're not driven to eat, they have the psychological and mental bandwidth to start tackling these other phenotypes that they have been unable to conquer, because they have the other ones under better control
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