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Clinical trials in patients with metabolic syndrome reveal that L-Carnitine supplementation of 2 g/day for extended periods (25-50 weeks) significantly reduces fasting blood glucose, HbA1c, homeostatic model assessment-insulin resistance (HOMA-IR), inflammatory markers including C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-), and triglyceride levels

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It is unknown if asymptomatic patients treated with L-Carnitine could still be susceptible to cardiac arrhythmia because of undiagnosed myocardial damage and fibrosis due to carnitine deficiency

Retatrutide dosing is the same in both versions