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Therefore, this review hypothesizes that mitochondria serve as central hubs regulating oxidative stress, inflammation, and aging, and their dysfunction contributes to various diseases, including cancers, cardiovascular diseases, neurodegenerative disorders, metabolic diseases, sepsis, ocular pathologies, liver diseases, and autoimmune conditions

It has been used in UK clinics since 2013 and is supplied through licensed pharmacy distribution

Catechol O-methyltransferases are responsible for transfer of a methyl group from S-adenosylmethionine to catecholamines such as norepinephrine, epinephrine and dopamine, being one of the major degradative pathways of the catecholamine transmitters

Zeevalk GD, Manzino L, Sonsalla PK, Bernard LP