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In homeostasis conditions, GSH is the most efficient physiological reducing agent with the highest bioavailability (~ 10 mM) in the intracellular environment where it is synthesized, except in epithelial cells [23]
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HFD causes an excessive production of ROS including MDA, and reduces the antioxidant enzyme levels, leading to increased insulin resistance (Helmi et al., 2021b)
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