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Schernthaner G, Gross JL, Rosenstock J, Guarisco M, Fu M, Yee J, et al

Leptin levels decline as adipose tissue mass decreases

This study aimed to address this knowledge gap by assessing the comparative effectiveness of these medications approved for obesity management among US adults with the disease of obesity, without diabetes in routine care settings

The most frequently reported adverse effects are gastrointestinal in nature , particularly during the initial weeks of treatment and following dose increases