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To view a copy of this license, visit About this article Cite this article Urbancsok, J., Bones, A.M
These metabolic dynamics are coupled with the regulation of protein lactylation, where p300/EP300, ACSS2, and AARS1/2 function as lactoyltransferases that catalyze the transfer of lactyl groups to lysine residues on target proteins, whereas HDACs and sirtuins act as delactylases that catalyze the removal of these modifications
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