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Tirzepatide exerts its therapeutic effects through dual agonism of two key incretin receptors: the GIPR and the GLP-1R
2022 R&D Spend: In 2022, Merck KGaA (Life Science and Healthcare divisions only) spent 2.02 billion ($2.13 billion USD) on R&D, a 1.70 percent decrease from the 2.06 billion ($2.43 billion USD) the companys Life Science and Healthcare divisions spent on R&D in 2021
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