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NSAIDs (ibuprofen, naproxen, aspirin): These directly irritate the stomach lining and can weaken the esophageal sphincter
A separate JAMA Health Forum analysis found semaglutide would need a very large price reduction to meet common cost-effectiveness thresholds, and tirzepatide would also require further price cuts to become cost-effective in that model
And beyond the cost, there is the inconvenience of waiting for a replacement, the possibility of missing doses, and the disruption to a treatment plan that was finally working
Horowitz JM, Horwitz BA
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