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Novo's pill is the gold standard but it has a strict fasted-dosing window

Jun 7 2017;18(6)doi:10.3390/ijms18061221

The mechanism by which epitalon stimulates pineal melatonin production is not fully elucidated, but may involve activation of genes encoding enzymes in the melatonin biosynthetic pathway (particularly N-acetyltransferase, the rate-limiting enzyme for melatonin synthesis) or restoration of pineal cell function in aging tissue