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Through lumbar puncture, CSF is collected, and neurotransmitter levels or their metabolites (such as acetylcholine metabolites or tau protein) are measured

A 2026 review in the New England Journal of Medicine noted that questions about long-term dosing and durability of results remain open areas of research, not settled strategy

Tseng (2016) showed that among Taiwanese patients with T2DM, sitagliptin use may be associated with an increased risk of TC