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Here, ovariectomy-induced bone loss was validated by a significant decrease in femoral, tibial, and lower spine BMD in the osteoporotic group compared to the other group
However, the -helical extension in TM1 of GIPR provides additional residues for tirzepatide recognition including one hydrogen bond (Y10 P and Q138 1.40b ) and a stacking interaction (K16 P and F127 1.29b )
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