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These medications have also demonstrated positive effects on fatty liver disease, enhancing their appeal in managing obesity-related conditions
Safety profile in PIONEER trials: Nausea: 11% to 20% (dose-dependent) Diarrhea: 8% to 11% Vomiting: 5% to 9% Discontinuation due to GI side effects: 4% to 7% The side effect rates are lower than injectable semaglutide at weight-loss doses, likely because the systemic exposure is lower
This suggests that for retatrutide, the final maintenance dose may be more significant than the speed of reaching it
The most common problems are with the stomach and intestines
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